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In the follow-up to the worldwide hit, Alien vs. Predator, two of the deadliest extra-terrestrial lifeforms from two of the scariest film franchises ever wage their most brutal battle yet in an unsuspecting Colorado town.

When a Predator scout ship crash-lands in the hills outside the town, Alien facehuggers are released in the crash, and an even more evil creature - a hybrid Alien/Predator - is also released. A man & his son hunting in the forests near the crash site soon become the first victims of the facehuggers, and when a Predator receives data about the crash on his home planet, he comes to Earth. One at a time, the inhabitants of the town become targets of the Aliens and the Predator, including the local sheriff, a young female soldier recently returned from Iraq, and several teens. Though the National Guard is called in, they are unable to stop the deadly creatures, and a plan is set in motion to destroy the town with a nuclear device...